Stealth filaments: Polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X.

ABSTRACT: Nanoparticles hold great promise for delivering medical cargos to cancerous tissues to enhance contrast and sensitivity of imaging agents or to increase specificity and efficacy of therapeutics. A growing body of data suggests that nanoparticle shape, in combination with surface chemistry, affects their in vivo fates, with elongated filaments showing enhanced tumor targeting and tissue penetration, while promoting immune evasion. The synthesis of high aspect ratio filamentous materials at the nanoscale remains challenging using synthetic routes; therefore we turned toward nature's materials, developing and studying the filamentous structures formed by the plant virus potato virus X (PVX). We recently demonstrated that PVX shows enhanced tumor homing in various preclinical models. Like othe

SUBMITTER: Lee KL 

PROVIDER: S-EPMC4411193 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature