The association of polymorphisms of TLR4 and CD14 genes with susceptibility to sepsis in a Chinese population.

ABSTRACT:

Background

Sepsis is now the leading cause of death in the non-cardiovascular intensive care unit (ICU). Recent research suggests that sepsis is likely to be due to an interaction between genetic and environmental factors. Genetic mutations of toll-like receptor 4 (TLR4) and cluster of differentiation 14 (CD14) genes are involved in the immune and (or) inflammatory response. These may contribute to the susceptibility to sepsis in patients. This study was designed to evaluate whether the TLR4 and cluster CD14 gene polymorphisms are associated with susceptibility to sepsis.

Methods

The single nucleotide polymorphisms (SNPs) of TLR4 (rs10759932, rs11536889, rs7873784, rs12377632, rs1927907, rs1153879) and CD14 (rs2569190 and rs2563298) in patients with sepsis and control subjec

SUBMITTER: Wang H 

PROVIDER: S-EPMC4411696 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature