REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies.

ABSTRACT:

Background

Genes encoding transcription factors that constitute gene-regulatory networks and maternal factors accumulating in egg cytoplasm are two classes of essential genes that play crucial roles in developmental processes. Transcription factors control the expression of their downstream target genes by interacting with cis-regulatory elements. Maternal factors initiate embryonic developmental programs by regulating the expression of zygotic genes and various other events during early embryogenesis.

Results

This article documents the transcription factors of 77 metazoan species as well as human and mouse maternal factors. We improved the previous method using a statistical approach adding Gene Ontology information to Pfam based identification of transcription factors. Thi

SUBMITTER: Wang K 

PROVIDER: S-EPMC4411712 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature