Prescription opioid epidemic and infant outcomes.

ABSTRACT:

Background and objectives

Although opioid pain relievers are commonly prescribed in pregnancy, their association with neonatal outcomes is poorly described. Our objectives were to identify neonatal complications associated with antenatal opioid pain reliever exposure and to establish predictors of neonatal abstinence syndrome (NAS).

Methods

We used prescription and administrative data linked to vital statistics for mothers and infants enrolled in the Tennessee Medicaid program between 2009 and 2011. A random sample of NAS cases was validated by medical record review. The association of antenatal exposures with NAS was evaluated by using multivariable logistic regression, controlling for maternal and infant characteristics.

Results

Of 112,029 pregnant women, 31,354 (28

SUBMITTER: Patrick SW 

PROVIDER: S-EPMC4411781 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature