Is the polymorphism at position -1082 of IL-10 gene associated with visceral leishmaniasis?

ABSTRACT:

Background

Immune responses play critical roles in the leishmaniasis eradication. IL-10 is a key regulator of immune responses, and the polymorphisms within its promoter region are associated with alteration in its expression. Therefore, this study was designed to examine the correlation between polymorphism at the -1082 position of the IL-10 gene and visceral leishmaniasis (VL).

Methods

The IL-10 -1082 polymorphism and anti-Leishmania antibody titration were examined in 110 patients with clinical presentation of VL and seropositive for the Leishmania (group 1), 74 seropositive patients but without clinical presentation (group 2) and 113 healthy controls (group 3) using the PCR-RFLP and immunofluorescence techniques, respectively.

Results

The polymorphism at IL-10 -10

SUBMITTER: Hajilooi M 

PROVIDER: S-EPMC4411907 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature