Early life body fatness and risk of colorectal cancer in u.s. Women and men-results from two large cohort studies.

ABSTRACT:

Background

The association between body fatness before adulthood and later risk of colorectal cancer remains unclear. We hypothesized that, independent of adult body fatness, early life body fatness would be associated with a higher risk of developing colorectal cancer.

Methods

We assessed body fatness during childhood and adolescence using a validated 9-level somatotype and inquired body weight in young adulthood in the Nurses' Health Study and Health Professionals Follow-up Study. We used the Cox proportional hazard regression modeling to estimate relative risks [RR, 95% confidence intervals (CI)] adjusting for adult body mass index (BMI) and other known colorectal cancer risk factors.

Results

We identified 2,100 incident colorectal cancer cases (1,292 in women and

SUBMITTER: Zhang X 

PROVIDER: S-EPMC4412364 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature