Ontology highlight
ABSTRACT:
SUBMITTER: Jaitin DA
PROVIDER: S-EPMC4412462 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Jaitin Diego Adhemar DA Kenigsberg Ephraim E Keren-Shaul Hadas H Elefant Naama N Paul Franziska F Zaretsky Irina I Mildner Alexander A Cohen Nadav N Jung Steffen S Tanay Amos A Amit Ido I
Science (New York, N.Y.) 20140201 6172
In multicellular organisms, biological function emerges when heterogeneous cell types form complex organs. Nevertheless, dissection of tissues into mixtures of cellular subpopulations is currently challenging. We introduce an automated massively parallel single-cell RNA sequencing (RNA-seq) approach for analyzing in vivo transcriptional states in thousands of single cells. Combined with unsupervised classification algorithms, this facilitates ab initio cell-type characterization of splenic tissu ...[more]