Altered insular activation and increased insular functional connectivity during sad and happy face processing in adolescent major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a leading cause of disability worldwide and occurs commonly first during adolescence. The insular cortex (IC) plays an important role in integrating emotion processing with interoception and has been implicated recently in the pathophysiology of adult and adolescent MDD. However, no studies have yet specifically examined the IC in adolescent MDD during processing of faces in the sad-happy continuum. Thus, the aim of the present study is to investigate the IC during sad and happy face processing in adolescents with MDD compared to healthy controls (HCL).

Methods

Thirty-one adolescents (22 female) with MDD and 36 (23 female) HCL underwent a well-validated emotional processing fMRI paradigm that included sad and happy face stimuli.<

SUBMITTER: Henje Blom E 

PROVIDER: S-EPMC4412607 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature