Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach.

ABSTRACT:

Background

Artemisinin-resistant falciparum malaria has emerged in Southeast Asia, posing a major threat to malaria control. It is characterised by delayed asexual-stage parasite clearance, which is the reference comparator for the molecular marker 'Kelch 13' and in vitro sensitivity tests. However, current cut-off values denoting slow clearance based on the proportion of individuals remaining parasitaemic on the third day of treatment ('day-3'), or on peripheral blood parasite half-life, are not well supported. We here explore the parasite clearance distributions in an area of artemisinin resistance with the aim refining the in vivo phenotypic definitions.

Methods and findings

Data from 1,518 patients on the Thai-Myanmar and Thai-Cambodian borders with parasite half-life as

SUBMITTER: White LJ 

PROVIDER: S-EPMC4412633 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature