Protective effects of myricetin on acute hypoxia-induced exercise intolerance and mitochondrial impairments in rats.

ABSTRACT:

Purpose

Exercise tolerance is impaired in hypoxia. The aim of this study was to evaluate the effects of myricetin, a dietary flavonoid compound widely found in fruits and vegetables, on acute hypoxia-induced exercise intolerance in vivo and in vitro.

Methods

Male rats were administered myricetin or vehicle for 7 days and subsequently spent 24 hours at a barometric pressure equivalent to 5000 m. Exercise capacity was then assessed through the run-to-fatigue procedure, and mitochondrial morphology in skeletal muscle cells was observed by transmission electron microscopy (TEM). The enzymatic activities of electron transfer complexes were analyzed using an enzyme-linked immuno-sorbent assay (ELISA). mtDNA was quantified by real-time-PCR. Mitochondrial membrane potential was meas

SUBMITTER: Zou D 

PROVIDER: S-EPMC4412664 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature