Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells.

ABSTRACT: Obesity has been implicated as a significant risk factor for development of pancreatic cancer. In the setting of obesity, a systemic chronic inflammatory response is characterized by alterations in the production and secretion of a wide variety of growth factors. Leptin is a hormone whose level increases drastically in the serum of obese patients. High fat diet induced obesity in mice leads to an overall increased body weight, pancreatic weight, serum leptin, and pancreatic tissue leptin levels. Here we report the contribution of obesity and leptin to pancreatic cancer growth utilizing an in vivo orthotopic murine pancreatic cancer model, which resulted in increased tumor proliferation with concomitant increased tumor burden in the diet induced obese mice compared to lean mice. Human and m

SUBMITTER: Mendonsa AM 

PROVIDER: S-EPMC4412670 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature