Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders.

ABSTRACT: Language and communication development is a complex process influenced by numerous environmental and genetic factors. Many neurodevelopment disorders include deficits in language and communication skills in their diagnostic criteria, including autism spectrum disorders (ASD), language impairment (LI), and dyslexia. These disorders are polygenic and complex with a significant genetic component contributing to each. The similarity of language phenotypes and comorbidity of these disorders suggest that they may share genetic contributors. To test this, we examined the association of genes previously implicated in dyslexia, LI, and/or language-related traits with language skills in children with ASD. We used genetic and language data collected in the Autism Genome Research Exchange (AGRE) and S

SUBMITTER: Eicher JD 

PROVIDER: S-EPMC4412753 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature