Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder.

ABSTRACT:

Objective

Genes and the environment both play a major role in the risk for attempted suicide, and environments harboring stressors, such as early childhood abuse, have been linked to suicidal behavior. Such environments also disrupt the hypothalamic-pituitary-adrenal (HPA) axis pathway, which has been hypothesized to play a role in suicidal behavior. We investigated whether the risk for attempted suicide was attributable in part to the interaction between childhood physical and/or sexual abuse and genetic variation in 19 genes (±5 kb) integral to the HPA axis pathway.

Materials and methods

Using the Genetic Association Information Network Bipolar Disorder and Translational Genomics Research Institute cohorts, we implemented PLINK's logistic regression-based 'interaction' app

SUBMITTER: Breen ME 

PROVIDER: S-EPMC4412784 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature