Polygenic risk, stressful life events and depressive symptoms in older adults: a polygenic score analysis.

ABSTRACT:

Background

Previous studies suggest that the relationship between genetic risk and depression may be moderated by stressful life events (SLEs). The goal of this study was to assess whether SLEs moderate the association between polygenic risk of major depressive disorder (MDD) and depressive symptoms in older adults.

Method

We used logistic and negative binomial regressions to assess the associations between polygenic risk, SLEs and depressive symptoms in a sample of 8761 participants from the Health and Retirement Study. Polygenic scores were derived from the Psychiatric Genomics Consortium genome-wide association study of MDD. SLEs were operationalized as a dichotomous variable indicating whether participants had experienced at least one stressful event during the previous

SUBMITTER: Musliner KL 

PROVIDER: S-EPMC4412793 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature