Coexpression Pattern Analysis of NPM1-Associated Genes in Chronic Myelogenous Leukemia.

ABSTRACT:

Background

Nucleophosmin 1 (NPM1) plays an important role in ribosomal synthesis and malignancies, but NPM1 mutations occur rarely in the blast-crisis and chronic-phase chronic myelogenous leukemia (CML) patients. The NPM1-associated gene set (GCM_NPM1), in total 116 genes including NPM1, was chosen as the candidate gene set for the coexpression analysis. We wonder if NPM1-associated genes can affect the ribosomal synthesis and translation process in CML.

Results

We presented a distribution-based approach for gene pair classification by identifying a disease-specific cutoff point that classified the coexpressed gene pairs into strong and weak coexpression structures. The differences in the coexpression patterns between the normal and the CML groups were reflected from the ov

SUBMITTER: Wang F 

PROVIDER: S-EPMC4413041 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature