Studies toward the total synthesis of Itralamide B and biological evaluation of its structural analogs.

ABSTRACT: Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 μM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itralamide B and the results derived from biological tests of these structural congeners.

SUBMITTER: Wang X 

PROVIDER: S-EPMC4413201 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature