Ontology highlight
ABSTRACT:
SUBMITTER: Turkarslan S
PROVIDER: S-EPMC4413241 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Turkarslan Serdar S Peterson Eliza J R EJ Rustad Tige R TR Minch Kyle J KJ Reiss David J DJ Morrison Robert R Ma Shuyi S Price Nathan D ND Sherman David R DR Baliga Nitin S NS
Scientific data 20150331
Mycobacterium tuberculosis (MTB) is a pathogenic bacterium responsible for 12 million active cases of tuberculosis (TB) worldwide. The complexity and critical regulatory components of MTB pathogenicity are still poorly understood despite extensive research efforts. In this study, we constructed the first systems-scale map of transcription factor (TF) binding sites and their regulatory target proteins in MTB. We constructed FLAG-tagged overexpression constructs for 206 TFs in MTB, used ChIP-seq t ...[more]