NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation.

ABSTRACT: Ionizing radiation (IR) causes not only acute tissue damage, but also late effects in several cell generations after the initial exposure. The thyroid gland is one of the most sensitive organs to the carcinogenic effects of IR, and we have recently highlighted that an oxidative stress is responsible for the chromosomal rearrangements found in radio-induced papillary thyroid carcinoma. Using both a human thyroid cell line and primary thyrocytes, we investigated the mechanism by which IR induces the generation of reactive oxygen species (ROS) several days after irradiation. We focused on NADPH oxidases, which are specialized ROS-generating enzymes known as NOX/DUOX. Our results show that IR induces delayed NADPH oxidase DUOX1-dependent H2O2 production in a dose-dependent manner, which is sus

SUBMITTER: Ameziane-El-Hassani R 

PROVIDER: S-EPMC4413347 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature