In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging.

ABSTRACT: Chronic traumatic encephalopathy (CTE) is an acquired primary tauopathy with a variety of cognitive, behavioral, and motor symptoms linked to cumulative brain damage sustained from single, episodic, or repetitive traumatic brain injury (TBI). No definitive clinical diagnosis for this condition exists. In this work, we used [F-18]FDDNP PET to detect brain patterns of neuropathology distribution in retired professional American football players with suspected CTE (n = 14) and compared results with those of cognitively intact controls (n = 28) and patients with Alzheimer's dementia (AD) (n = 24), a disease that has been cognitively associated with CTE. [F-18]FDDNP PET imaging results in the retired players suggested the presence of neuropathological patterns consistent with models of concussi

SUBMITTER: Barrio JR 

PROVIDER: S-EPMC4413350 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature