Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry.

ABSTRACT: Breast cancer incidence is increasing worldwide, and breast cancer-related mortality is highest in women of African ancestry, who are more likely to have basal-like or triple-negative breast cancer (TNBC) than are women of European ancestry. Identification of cultural, epidemiological, and genetic risk factors that predispose women of African ancestry to TNBC is an active area of research. Despite the aggressive behaviour of TNBC, achievement of a pathological complete response with chemotherapy is associated with good long-term survival outcomes, and sensitivity to chemotherapy does not seem to differ according to ethnic origin. Discovery of the molecular signalling molecules that define TNBC heterogeneity has led to the development of targeted agents such as inhibitors of poly (ADP-ribos

SUBMITTER: Brewster AM 

PROVIDER: S-EPMC4413447 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature