Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases.

ABSTRACT:

Introduction

Breast cancer cells display preferences for specific metastatic sites including the bone, lung and liver. Metastasis is a complex process that relies, in part, on interactions between disseminated cancer cells and resident/infiltrating stromal cells that constitute the metastatic microenvironment. Distinct immune infiltrates can either impair the metastatic process or conversely, assist in the seeding, colonization and growth of disseminated cancer cells.

Methods

Using in vivo selection approaches, we previously isolated 4T1-derived breast cancer cells that preferentially metastasize to these organs and tissues. In this study, we examined whether the propensity of breast cancer cells to metastasize to the lung, liver or bone is associated with and dependent on d

SUBMITTER: Tabaries S 

PROVIDER: S-EPMC4413545 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature