Association between SERPING1 rs2511989 polymorphism and age-related macular degeneration: Meta-analysis.

ABSTRACT:

Aim

To investigate the association between SERPING1 rs2511989 (G>A) polymorphism and age-related macular degeneration (AMD).

Methods

A number of electronic databases (up to July 15, 2014) were searched independently by two investigators. A Meta-analysis was performed on the association between SERPING1 rs2511989 polymorphism and AMD. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated.

Results

Eight studies with 16 cohorts consisting of 9163 cases and 6813 controls were included in this Meta-analysis. There was no significant association between rs2511989 polymorphism and AMD under all genetic models in overall estimates (A vs G: OR= 0.938, 95%CI =0.858-1.025; AA vs GG:OR =0.871, 95%CI =0.719-1.056; AG vs GG: OR =0.944, 95%CI =0.845-1.054; AA+A

SUBMITTER: Dong Y 

PROVIDER: S-EPMC4413591 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature