Ontology highlight
ABSTRACT:
SUBMITTER: Zhang QQ
PROVIDER: S-EPMC4413642 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Oncotarget 20150201 5
Slit2 is often overexpressed in cancers. Slit2 is a secreted protein that binds to Roundabout (Robo) receptors to regulate cell growth and migration. Here, we employed several complementary mouse models of intestinal cancers, including the Slit2 transgenic mice, the ApcMin/+ spontaneous intestinal adenoma mouse model, and the DMH/DSS-induced colorectal carcinoma model to clarify function of Slit2/Robo1 signaling in intestinal tumorigenesis. We showed that Slit2 and Robo1 are overexpressed in int ...[more]