Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms.

ABSTRACT:

Introduction

For many tumors, the overexpression of the chemokine receptor CXCR4 is associated with increased malignancy and poor patient outcomes. However, comprehensive data for neuroendocrine neoplasms of the lung are still lacking.

Methods

CXCR4 expression was evaluated in a panel of bronchopulmonary neuroendocrine neoplasms (BP-NEN) comprising typical carcinoids (n = 26), atypical carcinoids (n = 30), and small cell lung cancers (SCLC, n = 34). Samples were analyzed by immunohistochemistry using the novel monoclonal rabbit anti-human CXCR4 antibody UMB-2 and by qRT-PCR. The expression was correlated with clinical data and overall patient survival.

Results

CXCR4 was predominantly localized at the plasma membrane of the tumor cells. CXCR4 was expressed with a high

SUBMITTER: Kaemmerer D 

PROVIDER: S-EPMC4413658 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature