MRI in Leber's hereditary optic neuropathy: the relationship to multiple sclerosis.

ABSTRACT:

Background

Leber's hereditary optic neuropathy (LHON) and a multiple sclerosis (MS)-like illness appear to coexist 50 times more frequently than would be expected by chance. This association of LHON and MS (LMS) raises an important question about whether there could be a common pathophysiological mechanism involving mitochondrial dysfunction.

Objective

The primary aim was to define MRI features of LMS and LHON, and to assess the proportions of individuals displaying features typical of MS. Secondarily, we investigated the effect of gender on the risk of developing white matter lesions in the context of LHON.

Methods

A blinded standardised review of conventional brain MRIs of 30 patients with MS, 31 patients with LHON and 11 patients with LMS was conducted by three ind

SUBMITTER: Matthews L 

PROVIDER: S-EPMC4413690 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature