Risk of gastrointestinal bleeding associated with oral anticoagulants: population based retrospective cohort study.

ABSTRACT:

Objectives

To determine the real world safety of dabigatran or rivaroxaban compared with warfarin in terms of gastrointestinal bleeding.

Design

Retrospective cohort study.

Setting

Large administrative database of commercially insured people in United States from 1 October 2010 through 31 March 2012.

Participants

Enrollees with a prescription of warfarin, dabigatran, or rivaroxaban between 1 October 2010 and 31 March 2012, who were aged 18 years or older, had continuous enrollment and no oral anticoagulant use during the six months before the entry date, with known age and sex, and with no gastrointestinal bleeding for at least six months before the cohort entry date. The final study sample of 46,163 patients included 4907 using dabigatran, 1649 using rivaroxaba

SUBMITTER: Chang HY 

PROVIDER: S-EPMC4413867 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature