Additive Effect of Pronase on the Eradication Rate of First-Line Therapy for Helicobacter pylori Infection.

ABSTRACT:

Background/aims

Helicobacter pylori colonizes on the apical surface of gastric surface mucosal cells and the surface mucous gel layer. Pronase is a premedication enzyme for endoscopy that can disrupt the gastric mucus layer. We evaluated the additive effects of pronase combined with standard triple therapy for H. pylori eradication.

Methods

This prospective, single-blinded, randomized, controlled study was conducted between June and October 2012. A total of 116 patients with H. pylori infection were enrolled in the study (n=112 patients, excluding four patients who failed to meet the inclusion criteria) and were assigned to receive either the standard triple therapy, which consists of a proton pump inhibitor with amoxicillin and clarithromycin twice a day for 7 days (PAC), o

SUBMITTER: Bang CS 

PROVIDER: S-EPMC4413967 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature