Dynamic regulation of mRNA decay during neural development.

ABSTRACT:

Background

Gene expression patterns are determined by rates of mRNA transcription and decay. While transcription is known to regulate many developmental processes, the role of mRNA decay is less extensively defined. A critical step toward defining the role of mRNA decay in neural development is to measure genome-wide mRNA decay rates in neural tissue. Such information should reveal the degree to which mRNA decay contributes to differential gene expression and provide a foundation for identifying regulatory mechanisms that affect neural mRNA decay.

Results

We developed a technique that allows genome-wide mRNA decay measurements in intact Drosophila embryos, across all tissues and specifically in the nervous system. Our approach revealed neural-specific decay kinetics, includi

SUBMITTER: Burow DA 

PROVIDER: S-EPMC4413985 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature