RACK1 is a candidate gene associated with the prognosis of patients with early stage non-small cell lung cancer.

ABSTRACT:

Background

This study was conducted to identify genetic polymorphisms associated with the prognosis of patients with early stage NSCLC.

Materials and methods

We genotyped 1,969 potentially functional single nucleotide polymorphisms (SNPs) of 1,151 genes involved in carcinogenesis in 166 NSCLC patients who underwent curative surgery, using the Affymetrix custom-made GeneChip. A replication study was performed in an independent cohort of 626 patients.

Results

Fifty six SNPs which were associated with both overall survival (OS) and disease-free survival (DFS) with log-rank P values < 0.05 in discovery set were selected for validation. Among those, five SNPs (RACK1 rs1279736C>A and rs3756585T>G, C3 rs2287845T>C, PCAF rs17006625A>G, and PCM1 rs17691523C>G) were found to be

SUBMITTER: Choi YY 

PROVIDER: S-EPMC4414203 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature