Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma.

ABSTRACT:

Purpose

Despite significant improvement in locoregional control in the contemporary era of nasopharyngeal carcinoma (NPC) treatment, patients still suffer from a significant risk of distant metastasis (DM). Identifying those patients at risk of DM would aid in personalized treatment in the future. MicroRNAs (miRNAs) play many important roles in human cancers; hence, we proceeded to address the primary hypothesis that there is a miRNA expression signature capable of predicting DM for NPC patients.

Methods and results

The expression of 734 miRNAs was measured in 125 (Training) and 121 (Validation) clinically annotated NPC diagnostic biopsy samples. A 4-miRNA expression signature associated with risk of developing DM was identified by fitting a penalized Cox Proportion Hazard r

SUBMITTER: Bruce JP 

PROVIDER: S-EPMC4414210 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature