Synthetic RNA recognition motifs that selectively recognize HIV-1 trans-activation response element hairpin RNA.

ABSTRACT: A multitude of RNA hairpins are directly implicated in human disease. Many of these RNAs are potentially valuable targets for drug discovery and basic research. However, very little is known about the molecular requirements for achieving sequence-selective recognition of a particular RNA sequence and structure. Although a relatively modest number of synthetic small to medium-sized RNA-binding molecules have been reported, rapid identification of sequence-selective RNA-binding molecules remains a daunting challenge. RNA recognition motif (RRM) domains may represent unique privileged scaffolds for the generation of synthetic proteins that selectively recognize structured disease-relevant RNAs, including RNA hairpins. As a demonstration of this potential, we mutated putative RNA-binding regio

SUBMITTER: Blakeley BD 

PROVIDER: S-EPMC4414246 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature