Feasibility and safety of continuous and chronic bilateral deep brain stimulation of the medial forebrain bundle in the naive Sprague-Dawley rat.

ABSTRACT:

Objective

Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (MFB) has provided rapid and dramatic reduction of depressive symptoms in a clinical trial. Early intracranial self-stimulation experiments of the MFB suggested detrimental side effects on the animals' health; therefore, the current study looked at the viability of chronic and continuous MFB-DBS in rodents, with particular attention given to welfare issues and identification of stimulated pathways.

Methods

Sprague-Dawley female rats were submitted to stereotactic microelectrode implantation into the MFB. Chronic continuous DBS was applied for 3-6 weeks. Welfare monitoring and behavior changes were assessed. Postmortem histological analysis of c-fos protein expression was carried

SUBMITTER: Furlanetti LL 

PROVIDER: S-EPMC4414266 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature