Detection of MMTV-Like sequences in Moroccan breast cancer cases.

ABSTRACT:

Introduction

The mouse mammary tumor virus (MMTV) like sequences have been reported to be present in some human breast cancers, but their association with breast cancer development is still controversial.

Methods

In this retrospective study, we investigated the status of MMTV-like in 42 tumor biopsies and 18 paired normal tissues from Moroccan patients with breast cancer. MMTV-like env sequences were identified by PCR and confirmed by direct DNA sequencing.

Results

Specific MMTV-like env sequences were found in 24 (57.14%) cases of breast carcinomas, and 6 (33.3%) cases of matched normal breast tissues. Comparison to sociologic and clinicopathological parameters showed no significant association between the presence of MMTV-like sequences and age, menopausal status, h

SUBMITTER: Slaoui M 

PROVIDER: S-EPMC4414294 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature