Computel: computation of mean telomere length from whole-genome next-generation sequencing data.

ABSTRACT: Telomeres are the ends of eukaryotic chromosomes, consisting of consecutive short repeats that protect chromosome ends from degradation. Telomeres shorten with each cell division, leading to replicative cell senescence. Deregulation of telomere length homeostasis is associated with the development of various age-related diseases and cancers. A number of experimental techniques exist for telomere length measurement; however, until recently, the absence of tools for extracting telomere lengths from high-throughput sequencing data has significantly obscured the association of telomere length with molecular processes in normal and diseased conditions. We have developed Computel, a program in R for computing mean telomere length from whole-genome next-generation sequencing data. Computel is ope

SUBMITTER: Nersisyan L 

PROVIDER: S-EPMC4414351 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature