Association of C5aR1genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.

ABSTRACT:

Background

Complement 5a receptor (C5aR) was demonstrated a receptor of complement 5a (C5a) which is involved in many inflammatory diseases. The functional responses attributed to C5a results from its interaction with its receptors C5aR, which stimulates food intake, plays a role in increasing the inflammatory response in adipose tissue as well as the cardiovascular and neural systems. However, There are unknown associations between the SNPs of C5aR1 gene and coronary artery disease (CAD).

Methods

We examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5aR1 gene for CAD using a case-control design, and determined the prevalence of C5aR1 genotypes in 505 CAD patients and 469 age and sex-matched healthy control subjects of Han population.

Results

SUBMITTER: Zheng YY 

PROVIDER: S-EPMC4414445 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature