Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis.

ABSTRACT:

Importance

Atopic dermatitis (AD) is a common chronic illness of childhood.

Objective

To evaluate the association between thymic stromal lymphopoietin (TSLP) variation and the persistence of skin symptoms of AD.

Design, setting, and participants

A prospective cohort study was conducted in the general community. Participants included 796 children enrolled in the Pediatric Eczema Elective Registry. EXPOSURE Evaluation of TSLP variation.

Main outcomes and measures

Self-reported outcome of whether a child's skin had no symptoms of AD and required no medications for 6 months at 6-month intervals.

Results

We evaluated 14 variants of TSLP. The variant rs1898671 was significantly associated with the outcome in white children (P = .01). As measured by overlapping

SUBMITTER: Margolis DJ 

PROVIDER: S-EPMC4414492 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature