Creatinine clearance, walking speed, and muscle atrophy: a cohort study.

ABSTRACT:

Background

Chronic kidney disease is associated with malnutrition and inflammation. These processes may lead to loss of skeletal muscle and reduced physical performance. Associations of kidney function with muscle composition and longitudinal measures of physical performance are unknown.

Study design

Prospective cohort study.

Setting & participants

We evaluated 826 community-dwelling older adults enrolled in the Invecchiare in Chianti (InCHIANTI) Study who were free of baseline stroke or activities of daily living disability.

Predictor

Baseline creatinine clearance (Clcr) based on 24-hour urine collection.

Outcomes

Cross-sectional and longitudinal trajectories of physical performance measured by 7-m usual gait speed, 400-m fast gait speed, and knee exten

SUBMITTER: Roshanravan B 

PROVIDER: S-EPMC4414665 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature