Multimodal characterization of proliferative diabetic retinopathy reveals alterations in outer retinal function and structure.

ABSTRACT:

Purpose

To identify changes in retinal function and structure in persons with proliferative diabetic retinopathy (PDR), including the effects of panretinal photocoagulation (PRP).

Design

Cross-sectional study.

Participants

Thirty adults who underwent PRP for PDR, 15 adults with untreated PDR, and 15 age-matched controls.

Methods

Contrast sensitivity, frequency doubling perimetry (FDP), Humphrey visual fields, photostress recovery, and dark adaptation were assessed. Fundus photography and macular spectral-domain optical coherence tomography (SD OCT) were performed. To quantify retinal layer thicknesses, SD OCT scans were segmented semiautomatically.

Main outcome measures

Visual function measures were compared among patients with PDR and PRP, untreated pat

SUBMITTER: Boynton GE 

PROVIDER: S-EPMC4414692 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature