Chronic wound repair and healing in older adults: current status and future research.

ABSTRACT: The incidence of chronic wounds is increased among older adults, and the impact of chronic wounds on quality of life is particularly profound in this population. It is well established that wound healing slows with age. However, the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The impact of age and accompanying multi-morbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables, lack of standardization in data collection,

SUBMITTER: Gould L 

PROVIDER: S-EPMC4414710 | biostudies-literature | 2015 Jan-Feb

REPOSITORIES: biostudies-literature