Parental history of premature cardiovascular disease, estimated GFR, and rate of estimated GFR decline: results from the Aerobics Center Longitudinal Study.

ABSTRACT:

Background

Despite cardiovascular disease (CVD) and chronic kidney disease sharing similar causes and interplay, it is unknown if a broader relationship between these diseases exists across generations. We investigated the association between parental CVD history and estimated glomerular filtration rate (eGFR) in the community.

Study design

Cross-sectional and longitudinal analyses.

Setting & participants

13,241 community-based adults with serum creatinine measurement and follow-up visits (from 1-8 visits ~2 years apart) from the Aerobics Center Longitudinal Study.

Predictors

Premature parental CVD history (before age 50 years).

Outcomes

eGFR, decreased eGFR (<60 mL/min/1.73 m(2)), and rate of eGFR decline.

Measurements

Information for parental hi

SUBMITTER: Huang X 

PROVIDER: S-EPMC4414720 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature