Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure.

ABSTRACT:

Background and purpose

Long-term exposure to ambient air pollution is associated with cerebrovascular disease and cognitive impairment, but whether it is related to structural changes in the brain is not clear. We examined the associations between residential long-term exposure to ambient air pollution and markers of brain aging using magnetic resonance imaging.

Methods

Framingham Offspring Study participants who attended the seventh examination were at least 60 years old and free of dementia and stroke were included. We evaluated associations between exposures (fine particulate matter [PM2.5] and residential proximity to major roadways) and measures of total cerebral brain volume, hippocampal volume, white matter hyperintensity volume (log-transformed and extensive white ma

SUBMITTER: Wilker EH 

PROVIDER: S-EPMC4414870 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature