Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways.

ABSTRACT: Local mediators orchestrate the host response to both sterile and infectious challenge and resolution. Recent evidence demonstrates that maresin sulfido-conjugates actively resolve acute inflammation and promote tissue regeneration. In this report, we investigated self-limited infectious exudates for novel bioactive chemical signals in tissue regeneration and resolution. By use of spleens from Escherichia coli infected mice, self-resolving infectious exudates, human spleens, and blood from patients with sepsis, we identified 2 new families of potent molecules. Characterization of their physical properties and isotope tracking demonstrated that the bioactive structures contained a docosahexaenoate backbone and sulfido-conjugated triene or tetraene double-bond systems. Activated human phagoc

SUBMITTER: Dalli J 

PROVIDER: S-EPMC4415017 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature