IMOT: an interactive package for the selection of spatially interacting motifs.

ABSTRACT: Functional selection and three-dimensional structural constraints of proteins relate to the retention of significant sequence similarity between proteins of similar fold and function despite poor overall sequence identity and evolutionary pressures. We report the availability of 'iMOT' (interacting MOTif) server, an interactive package for the automatic identification of spatially interacting motifs among distantly related proteins sharing similar folds and possessing common ancestral lineage. Spatial interactions between conserved stretches of a protein are evaluated by calculations of pseudo-potentials that describe the strength of interactions. Such an evaluation permits the automatic identification of highly interacting conserved regions of a protein. Interacting motifs have been shown

SUBMITTER: Bhaduri A 

PROVIDER: S-EPMC441513 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature