The cyclical lower extremity exercise for Parkinson's trial (CYCLE): methodology for a randomized controlled trial.

ABSTRACT:

Background

Motor and non-motor impairments affect quality of life in individuals with Parkinson's disease. Our preliminary research indicates that forced exercise cycling, a mode of exercise in which a participant's voluntary rate of exercise is augmented on a stationary cycle, results in global improvements in the cardinal symptoms of Parkinson's disease. The objective of the Cyclical Lower Extremity Exercise (CYCLE) trial for Parkinson's disease is to determine the effects of forced exercise cycling on motor and non-motor performance when compared to voluntary rate cycling and a non-exercise control group. Additionally, we plan to identify any associated changes in neural activity determined by functional magnetic resonance imaging.

Methods/design

A total of 100 individual

SUBMITTER: Rosenfeldt AB 

PROVIDER: S-EPMC4415238 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature