A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.

ABSTRACT: Molecular interaction databases are essential resources that enable access to a wealth of information on associations between proteins and other biomolecules. Network graphs generated from these data provide an understanding of the relationships between different proteins in the cell, and network analysis has become a widespread tool supporting -omics analysis. Meaningfully representing this information remains far from trivial and different databases strive to provide users with detailed records capturing the experimental details behind each piece of interaction evidence. A targeted curation approach is necessary to transfer published data generated by primarily low-throughput techniques into interaction databases. In this review we present an example highlighting the value of both target

SUBMITTER: Porras P 

PROVIDER: S-EPMC4415485 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature