Hemorrhage rates from brain arteriovenous malformation in patients with hereditary hemorrhagic telangiectasia.

ABSTRACT:

Background and purpose

Hereditary hemorrhagic telangiectasia (HHT) is a systemic disease characterized by mucocutaneous telangiectasias, epistaxis, and arteriovenous malformations (AVMs). Intracranial hemorrhage (ICH) rates in this population are not well described. We report ICH rates and characteristics in HHT patients with brain AVMs (HHT-BAVMs).

Methods

We studied the first 153 HHT-BAVM patients with follow-up data enrolled in the Brain Vascular Malformation Consortium HHT Project. We estimated ICH rates after BAVM diagnosis.

Results

The majority of patients were women (58%) and white (98%). The mean age at BAVM diagnosis was 31±19 years (range, 0-70), with 61% of cases diagnosed on asymptomatic screening. Overall, 14% presented with ICH; among symptomatic cases,

SUBMITTER: Kim H 

PROVIDER: S-EPMC4415515 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature