Drug-induced regulatory overcompensation has motivational consequences: Implications for homeostatic and allostatic models of drug addiction.

ABSTRACT: Initial administration of 60% nitrous oxide (N₂O) at 21°C ambient temperature (Ta) reduces core temperature (Tc) in rats, but tolerance develops to this hypothermic effect over several administrations. After additional N₂O administrations, a hyperthermic overcompensation (sign-reversal) develops such that Tc exceeds control levels during N₂O inhalation. This study investigated whether rats would employ behavioral thermoregulation to facilitate, or oppose, a previously acquired hyperthermic overcompensation during N₂O administration. To establish a hyperthermic sign-reversal, male Long-Evans rats (N=12) received ten 3-h administrations of 60% N₂O while housed in a gas-tight, live-in, "inactive" thermal gradient (~21°C). Following the te

SUBMITTER: Ramsay DS 

PROVIDER: S-EPMC4415621 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature