ProteMiner-SSM: a web server for efficient analysis of similar protein tertiary substructures.

ABSTRACT: Analysis of protein-ligand interactions is a fundamental issue in drug design. As the detailed and accurate analysis of protein-ligand interactions involves calculation of binding free energy based on thermodynamics and even quantum mechanics, which is highly expensive in terms of computing time, conformational and structural analysis of proteins and ligands has been widely employed as a screening process in computer-aided drug design. In this paper, a web server called ProteMiner-SSM designed for efficient analysis of similar protein tertiary substructures is presented. In one experiment reported in this paper, the web server has been exploited to obtain some clues about a biochemical hypothesis. The main distinction in the software design of the web server is the filtering process incorp

SUBMITTER: Chang DT 

PROVIDER: S-EPMC441563 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature