Roles of solvent accessibility and gene expression in modeling protein sequence evolution.

ABSTRACT: Models of protein evolution tend to ignore functional constraints, although structural constraints are sometimes incorporated. Here we propose a probabilistic framework for codon substitution that evaluates joint effects of relative solvent accessibility (RSA), a structural constraint; and gene expression, a functional constraint. First, we explore the relationship between RSA and codon usage at the genomic scale as well as at the individual gene scale. Motivated by these results, we construct our framework by determining how probable is an amino acid, given RSA and gene expression, and then evaluating the relative probability of observing a codon compared to other synonymous codons. We come to the biologically plausible conclusion that both RSA and gene expression are related to amino aci

SUBMITTER: Wang K 

PROVIDER: S-EPMC4415675 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature