Determination of Zygosity in Adult Chinese Twins Using the 450K Methylation Array versus Questionnaire Data.

ABSTRACT: Previous studies have shown that both single nucleotide polymorphisms (SNPs) and questionnaires-based method can be used for twin zygosity determination, but few validation studies have been conducted using Chinese populations. In the current study, we recruited 192 same sex Chinese adult twin pairs to evaluate the validity of using genetic markers-based method and questionnaire-based method in zygosity determination. We considered the relatedness analysis based on more than 0.6 million SNPs genotyping as the golden standards for zygosity determination. After quality control, qualified twins were left for relatedness analysis based on identical by descent calculation. Then those same sex twin pairs were included in the zygosity questionnaire validation analysis. Logistic regression model w

SUBMITTER: Wang B 

PROVIDER: S-EPMC4415785 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature